The Short Life Story
of the Messenger NO
The walls of the blood vessels are covered by
smooth muscles that can contract and relax. When
plaque forms in an artery of the heart, the blood
flow diminishes. A clogged artery of the heart
suddenly goes into spasm, the amount of blood
going to the heart is reduced and chest pain occurs.
In this situation, the level of nitric oxide rises
causing dilation in the arteries that nourish
the heart muscles.
Every nitric oxide molecule lasts about 10 seconds.
It is designed to communicate its message within this
short time to the relevant recipients and do this perfectly
without fail. The messenger NO molecules secreted by
the endothelium cells are dispersed with great speed
in every direction. Those which are directed towards
the smooth muscle cells enter the membrane of these
cells. The smooth muscle cell membrane acts as a selector
giving entry to the NO it recognizes. Without wasting
any time, the NO molecule that enters the smooth muscle
cells finds a special enzyme called GC and communicates
its vitally important message. As a result, a series
of complex chemical reactions occur within the cell.
What we have called a messenger is a molecule, 0.000000001
meter in size, containing only two atoms. These tiny
molecules act as mail deliverers finding the GC enzyme
that is the recipient of the message they carry. There
are thousands of different enzymes performing different
functions inside cells. Despite this, the message is
delivered every time to the right address, that is,
to the correct enzyme. Moreover, messenger molecules
have a very limited life span, but they never make a
mistake in timing. The molecules that carry the messages
do not have a compass or similar device to show them
the direction, but they never lose their way.
The speed with which the nitric oxide molecule performs
its function can be compared to modern communication
by e-mail. NO acts just like an electronic postal system,
sending many messages at high speed to their destinations.
The speed at which the nitric oxide molecule delivers
its message can be compared to an electronic postal
When GC enzyme in the smooth muscle cells receives
the message brought by NO, it begins its activity. The
duty of this worker enzyme is to turn the GTP, the energy-carrying
molecules, into cGMP. The many reactions that occur
between these stages are still unknown.
To put it in most simplest terms, at the end of the
activity of the enzymes, the concentration of calcium
in the muscle cell diminishes, causing a separation
in the fibers and the relaxing of the muscle cells.
As a result of this, the vessels dilate. In short, the
message carried by the nitric oxide molecule has a vital
importance in the adjustment of the pressure in the
vessels, and what is explained here is only one of the
millions of complex communication operations that go
on every moment in our bodies.
How is it that NO molecules that have no intelligence
or consciousness know the perfect systems that world-renowned
professors can still not fathom? And how is it that
they know, to the last second, when they must begin
their activity and when they must end it? How is it
that, as soon as it is produced, as if it had received
a command from somewhere, it is able to deliver high-speed
messages to the right address, exactly on time and without
NO cannot perform these wonderful operations by itself.
This molecule, like millions of other molecules in nature,
is the work of a flawless creation, and it is a demonstration
of God's limitless power and knowledge.
A message-bearing hormone binds with receptors
on the artery. As a result of this bond, NO is
produced. The NO molecules travel towards the
smooth muscles and activate the GC enzyme there.
This worker enzyme converts the GTP, the energy
carrying molecules into cGMP. The cGMP causes
calcium ions to go to the storage areas in the
cell. As a result of these operations, the smooth
muscle cells relax and the blood vessels dilate.
The Production Facility For Nitric
Oxide: The Endothelial Cell
The amino acid known as Argentina-L, the nitric oxide
synthesis, nicotinamide adenine dinucleotide phosphate,
calmodulin, oxygen, flavin mononucleotide, flavine-adenine-dinucleotide,
The endothelial cell knows these microscopic materials
very well and uses them to produce nitric oxide molecules.
Using modern advanced technology, factories producing
chemical products are a trillion times trillion times
larger than endothelial cells. In spite of this, the
technology of the microscopic factory we call endothelium
is much more advanced than that of the giant industrial
installations that we are familiar with. The endothelial
cell, whose complex operations have been understood
only within the last ten years of the twentieth century,
accomplish all these without difficulty.
The endothelial cell knows what chemical material must
be used and in what proportion to produce the NO molecule.
There is no error in production. For example, N2O (laughing
gas) is not produced instead of NO. The production within
the endothelial cell never relies on chance; the balances
in the production are very delicate. At this point,
recall that if the endothelial cell produced fewer messengers
than required, our blood vessels would constrict, and
our blood pressure would rise quickly, causing a heart
attack. If too much is produced, our blood vessels would
dilate excessively, our blood pressure would fall too
low, and we would go into shock. But endothelial cells
never make such mistakes that could cause our deaths.
These cells are ready to produce NO at every moment
of our lives; when the need arises, the production goes
into action immediately. This tiny factory works very
efficiently; it does not store the NO molecules it produces,
so that problems associated with storage do not arise.
This remarkable factory in the depths of our blood
vessels does not produce unwanted by-products. If we
consider that global warming, acid rain, environmental
pollution and many other problems facing the world today
come from chemical waste, we can better understand how
efficient endothelial cells are. The nitric oxide molecules
do their job in only ten seconds and afterwards disintegrate
so that no dangerous side effects occur from their accumulation
in the body. All this means that endothelial cells use
the ideal method in the production of chemical products.
An industrial factory is the work of engineers and
workers. The systems in this factory show the highly
advanced technology of their designers. The endothelium
factory is the work of a superior Creator; this microscopic
factory, together with the other 100 trillion cells
in our body, clearly demonstrate the eternal knowledge